I. Contraindications
- Skin lesions infected with viruses (e.g., herpes simplex, chickenpox), fungal infections (e.g., candidiasis, tinea), or bacteria (e.g., impetigo); hypersensitivity to the preparation.
II. Warnings/Precautions
- For infants, diapers can act as occlusive dressings, increasing absorption.
- When treating infected inflammatory lesions, appropriate antimicrobial therapy should be used.
- If the infection spreads, topical corticosteroid therapy should be discontinued, and systemic antimicrobial agents should be administered. As with all corticosteroids, prolonged application to the face is not recommended.
- Topical corticosteroids used in pregnant animals can cause fetal malformations.
- Prolonged continuous use should be avoided as much as possible for infants and children.
- It can cause a occlusive dressing effect in infant diapers, increasing absorption.
- If an allergic reaction occurs, discontinue use immediately. When applying the cream to a large affected area of the body, some patients may absorb sufficient steroids, leading to adrenal suppression. Although the systemic effect of Clobetasone butyrate is not high, local skin atrophy may occur in situations where increased humidity increases the absorption of Clobetasone butyrate, but this only occurs after prolonged use.
This phenomenon has not been observed in humans; however, pregnant women should not use topical steroid medications extensively, i.e., they should not use them in large quantities or for extended periods. Prolonged or inappropriate use of topical corticosteroids can lead to rebound reactions (topical steroid withdrawal) after treatment cessation. Severe rebound reactions may extend beyond the initial treatment site, and symptoms may include dermatitis with intense redness, stinging, and burning sensations, especially when applied to more delicate skin areas such as the face and curved areas. If these symptoms reappear within days to weeks after successful treatment, a rebound reaction should be suspected. If it is necessary to resume the use of topical corticosteroids, carefully assess their clinical benefits and risks, or consider alternative treatment options.
III. Precautions for Special Groups – Pregnancy
- Pregnant women should not use these medications in large quantities or for extended periods.
IV. Precautions for Special Groups – Children
V. Side Effects/Adverse Reactions
Skin and subcutaneous tissue disorders – withdrawal symptoms (frequency unknown): Redness of the skin, which may spread beyond the initial treatment area; burning or stinging sensation; itching; peeling; oozing. Skin and subcutaneous tissue disorders – withdrawal symptoms (frequency unknown): Redness of the skin, which may spread beyond the initial treatment area; burning or stinging sensation; itching; peeling; oozing.
